4lqy
Crystal Structure of Human ENPP4 with AMPCrystal Structure of Human ENPP4 with AMP
FunctionFunction
[ENPP4_HUMAN] Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.[1]
About this StructureAbout this Structure
4lqy is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Albright RA, Chang WC, Robert D, Ornstein DL, Cao W, Liu L, Redick ME, Young JI, De La Cruz EM, Braddock DT. NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Blood. 2012 Nov 22;120(22):4432-40. doi: 10.1182/blood-2012-04-425215. Epub 2012 , Sep 20. PMID:22995898 doi:http://dx.doi.org/10.1182/blood-2012-04-425215
- ↑ Albright RA, Chang WC, Robert D, Ornstein DL, Cao W, Liu L, Redick ME, Young JI, De La Cruz EM, Braddock DT. NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Blood. 2012 Nov 22;120(22):4432-40. doi: 10.1182/blood-2012-04-425215. Epub 2012 , Sep 20. PMID:22995898 doi:http://dx.doi.org/10.1182/blood-2012-04-425215