3wi2

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Template:STRUCTURE 3wi2

Crystal structure of PDE10A in complex with inhibitorCrystal structure of PDE10A in complex with inhibitor

Template:ABSTRACT PUBMED 24238902

FunctionFunction

[PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1]

About this StructureAbout this Structure

3wi2 is a 2 chain structure. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Hamaguchi W, Masuda N, Isomura M, Miyamoto S, Kikuchi S, Amano Y, Honbou K, Mihara T, Watanabe T. Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition. Bioorg Med Chem. 2013 Dec 15;21(24):7612-23. doi: 10.1016/j.bmc.2013.10.035. Epub, 2013 Oct 31. PMID:24238902 doi:http://dx.doi.org/10.1016/j.bmc.2013.10.035
  1. ↑ Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5782-7. Epub 2007 Mar 26. PMID:17389385

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