4ian

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Template:STRUCTURE 4ian

Crystal Structure of apo Human PRPF4B kinase domainCrystal Structure of apo Human PRPF4B kinase domain

Template:ABSTRACT PUBMED 24003220

FunctionFunction

[PRP4B_HUMAN] Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

About this StructureAbout this Structure

4ian is a 2 chain structure with sequence from Streptomyces aureorectus. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Gao Q, Mechin I, Kothari N, Guo Z, Deng G, Haas K, McManus J, Hoffmann D, Wang A, Wiederschain D, Rocnik J, Czechtizky W, Chen X, McLean L, Arlt H, Harper D, Liu F, Majid T, Patel V, Lengauer C, Garcia-Echeverria C, Zhang B, Cheng H, Dorsch M, Huang SM. Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches. J Biol Chem. 2013 Sep 3. PMID:24003220 doi:10.1074/jbc.M113.473348

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