4ej1

Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complexBinding of Nb113 camelid antibody fragment with the binary DHFR:folate complex

FunctionFunction

[DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this StructureAbout this Structure

4ej1 is a 4 chain structure with sequence from Escherichia coli k-12 and Lama glama. Full crystallographic information is available from OCA.

ReferenceReference

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↑ Oyen D, Wechselberger R, Srinivasan V, Steyaert J, Barlow JN. Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli. Biochim Biophys Acta. 2013 Jul 31. pii: S1570-9639(13)00282-3. doi:, 10.1016/j.bbapap.2013.07.010. PMID:23911607 doi:10.1016/j.bbapap.2013.07.010

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OCA

[1] Oyen D, Wechselberger R, Srinivasan V, Steyaert J, Barlow JN. Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli. Biochim Biophys Acta. 2013 Jul 31. pii: S1570-9639(13)00282-3. doi:, 10.1016/j.bbapap.2013.07.010. PMID:23911607 doi:10.1016/j.bbapap.2013.07.010

[xtra 1]