4iqt

Tdt core in complex with inhibitor 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acidTdt core in complex with inhibitor 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid

FunctionFunction

[TDT_MOUSE] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

About this StructureAbout this Structure

4iqt is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Costi R, Cuzzucoli Crucitti G, Pescatori L, Messore A, Scipione L, Tortorella S, Amoroso A, Crespan E, Campiglia P, Maresca B, Novellino E, Gouge J, Delarue MH, Maga G, Di Santo R. New Nucleotide-Competitive Non-Nucleoside Inhibitors of Terminal Deoxynucleotidyl Transferase: Discovery, Characterization and Crystal Structure in Complex with the Target. J Med Chem. 2013 Aug 22. PMID:23968551 doi:10.1021/jm4010187

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OCA

[1] Costi R, Cuzzucoli Crucitti G, Pescatori L, Messore A, Scipione L, Tortorella S, Amoroso A, Crespan E, Campiglia P, Maresca B, Novellino E, Gouge J, Delarue MH, Maga G, Di Santo R. New Nucleotide-Competitive Non-Nucleoside Inhibitors of Terminal Deoxynucleotidyl Transferase: Discovery, Characterization and Crystal Structure in Complex with the Target. J Med Chem. 2013 Aug 22. PMID:23968551 doi:10.1021/jm4010187

[xtra 1]