4kyh

Crystal structure of mouse glyoxalase I complexed with zopolrestatCrystal structure of mouse glyoxalase I complexed with zopolrestat

FunctionFunction

[LGUL_MOUSE] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity).

About this StructureAbout this Structure

4kyh is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Zhai J, Zhang H, Zhang L, Zhao Y, Chen S, Chen Y, Peng X, Li Q, Yuan M, Hu X. Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis. ChemMedChem. 2013 Jul 15. doi: 10.1002/cmdc.201300243. PMID:23857942 doi:10.1002/cmdc.201300243

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OCA

[1] Zhai J, Zhang H, Zhang L, Zhao Y, Chen S, Chen Y, Peng X, Li Q, Yuan M, Hu X. Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis. ChemMedChem. 2013 Jul 15. doi: 10.1002/cmdc.201300243. PMID:23857942 doi:10.1002/cmdc.201300243

[xtra 1]