4j1l

Mutant Endotoxin TeNTMutant Endotoxin TeNT

FunctionFunction

[TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.

About this StructureAbout this Structure

4j1l is a 1 chain structure. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Guo J, Pan X, Zhao Y, Chen S. Engineering Clostridia Neurotoxins with elevated catalytic activity. Toxicon. 2013 Nov;74:158-66. doi: 10.1016/j.toxicon.2013.08.055. Epub 2013 Aug, 29. PMID:23994593 doi:http://dx.doi.org/10.1016/j.toxicon.2013.08.055

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Guo J, Pan X, Zhao Y, Chen S. Engineering Clostridia Neurotoxins with elevated catalytic activity. Toxicon. 2013 Nov;74:158-66. doi: 10.1016/j.toxicon.2013.08.055. Epub 2013 Aug, 29. PMID:23994593 doi:http://dx.doi.org/10.1016/j.toxicon.2013.08.055

[xtra 1]