2fom
Dengue Virus NS2B/NS3 Protease
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| , resolution 1.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Activity: | Flavivirin, with EC number 3.4.21.91 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
OverviewOverview
The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.
About this StructureAbout this Structure
2FOM is a Protein complex structure of sequences from Dengue virus type 3. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus., Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U, Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12. PMID:16532006
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