4hwp
Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitorCrystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor
FunctionFunction
[SYT_ECOLI] ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA.[HAMAP-Rule:MF_00184]
About this StructureAbout this Structure
4hwp is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Teng M, Hilgers MT, Cunningham ML, Borchardt A, Locke JB, Abraham S, Haley G, Kwan BP, Hall C, Hough GW, Shaw KJ, Finn J. Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J Med Chem. 2013 Feb 28;56(4):1748-60. doi: 10.1021/jm301756m. Epub 2013 Feb 12. PMID:23362938 doi:10.1021/jm301756m