4bhx

Crystal structure of the SCAN domain from human paternally expressed gene 3 proteinCrystal structure of the SCAN domain from human paternally expressed gene 3 protein

FunctionFunction

[PEG3_HUMAN] Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.^[1]

About this StructureAbout this Structure

4bhx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Rimsa V, Eadsforth TC, Hunter WN. Structure of the SCAN Domain of Human Paternally Expressed Gene 3 Protein. PLoS One. 2013 Jul 23;8(7):e69538. doi: 10.1371/journal.pone.0069538. Print 2013. PMID:23936039 doi:10.1371/journal.pone.0069538

↑ Kohda T, Asai A, Kuroiwa Y, Kobayashi S, Aisaka K, Nagashima G, Yoshida MC, Kondo Y, Kagiyama N, Kirino T, Kaneko-Ishino T, Ishino F. Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. Genes Cells. 2001 Mar;6(3):237-47. PMID:11260267

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OCA

[2] Rimsa V, Eadsforth TC, Hunter WN. Structure of the SCAN Domain of Human Paternally Expressed Gene 3 Protein. PLoS One. 2013 Jul 23;8(7):e69538. doi: 10.1371/journal.pone.0069538. Print 2013. PMID:23936039 doi:10.1371/journal.pone.0069538

[1] Kohda T, Asai A, Kuroiwa Y, Kobayashi S, Aisaka K, Nagashima G, Yoshida MC, Kondo Y, Kagiyama N, Kirino T, Kaneko-Ishino T, Ishino F. Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. Genes Cells. 2001 Mar;6(3):237-47. PMID:11260267

[1]

[xtra 1]