Template:STRUCTURE 4i6y

3-hydroxy-3-methyl (HMG) Coenzyme A Reductase bound to R-Mevalonate3-hydroxy-3-methyl (HMG) Coenzyme A Reductase bound to R-Mevalonate

Template:ABSTRACT PUBMED 23802607

FunctionFunction

[MVAA_PSEMV] P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA.

About this StructureAbout this Structure

4i6y is a 2 chain structure with sequence from Pseudomonas mevalonii. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. Steussy CN, Critchelow CJ, Schmidt TJ, Min JK, Wrensford LV, Burgner JW, Rodwell VW, Stauffacher CV. A novel role for CoA during hydride transfer in 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Biochemistry. 2013 Jun 26. PMID:23802607 doi:10.1021/bi400335g

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OCA