1h23
Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(12)-hupyridone at 2.15A resolutionStructure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(12)-hupyridone at 2.15A resolution
Template:ABSTRACT PUBMED 12517147
FunctionFunction
[ACES_TORCA] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
About this StructureAbout this Structure
1h23 is a 1 chain structure with sequence from Torpedo californica. Full crystallographic information is available from OCA.
See AlsoSee Also
- AChE bivalent inhibitors
- Acetylcholinesterase
- Torpedo Californica Acetylcholinesterase in complex with an (R)-Tacrine-(10)-Hupyridone inhibitor
- User:Dawn M. Wong
ReferenceReference
- ↑ Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL. Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity. J Am Chem Soc. 2003 Jan 15;125(2):363-73. PMID:12517147 doi:http://dx.doi.org/10.1021/ja021111w
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OCACategories:
- Acetylcholinesterase
- Torpedo californica
- Carlier, P R.
- Greenblatt, H M.
- Han, Y F.
- Pang, Y P.
- Silman, I.
- Sussman, J L.
- Wong, D M.
- Alzheimer's disease
- Bivalent ligand
- Dual-site binding
- Glycoprotein
- Gpi-anchor neurotransmitter degradation
- Huperzine some
- Hydrolase
- Inhibitor
- Membrane
- Muscle
- Nerve
- Neurotransmitter cleavage
- Serine esterase synapse
- Serine hydrolase