Antithrombin

Antithrombin (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interaction of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation.

3D structures of antithrombin3D structures of antithrombin

Updated on 17-November-2014

{"openlevels":0}

• Antithrombin
  • 1att – AT-III – bovine
  • 1ant, 2ant – hAT – human
  • 1e05 - hα-AT-III
  • 1e04 – hβ-AT-III
  • 1ath, 2znh, 4eb1 – hAT-III
  • 1dzg, 1oyh, 1t1f, 2beh, 2b4x, 2hij - hAT-III (mutant)
• Antithrombin binary complexes
  • 1azx, 1nq9, 3evj – hAT + heparin pentasaccharide
  • 1e03 – hα-AT-III + heparin pentasaccharide
  • 1dzh - hAT-III (mutant) + fluorescein
  • 2gd4 - hAT-III (mutant) + coagulation factor X
  • 1br8, 1jvq, 1lk6, 1r1l – hAT-III + peptide
• Antithrombin ternary complexes
  • 1sr5 - hAT-III + prothrombin + heparin heptasaccharide
  • 1tb6 - hAT-III (mutant) + thrombin + heparin polysaccharide
  • 2b5t - AT-III (mutant) + thrombin (mutant) + heparin polysaccharide
  • 3kcg - hAT-III (mutant) + coagulation factor IXa + heparin pentasaccharide