4e19

Crystal structure of RNase H1 from halophilic archaeon Halobacterium salinarum NRC-1Crystal structure of RNase H1 from halophilic archaeon Halobacterium salinarum NRC-1

Structural highlights

4e19 is a 2 chain structure with sequence from Halobacterium sp. nrc-1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	VNG_0255C (Halobacterium sp. NRC-1)
Activity:	Ribonuclease H, with EC number 3.1.26.4
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[RNH_HALSA] Nuclease that specifically degrades the RNA of RNA-DNA hybrids; seems to act exonucleolytically on RNA/DNA hybrids. Endonucleolytically removes RNA primers from the Okazaki fragments of lagging strand synthesis on its own. Complements the temperature-sensitive phenotype of an E.coli double rnhA/rnhB (RNase H) disruption mutant.^[1]

References

↑ Ohtani N, Yanagawa H, Tomita M, Itaya M. Identification of the first archaeal Type 1 RNase H gene from Halobacterium sp. NRC-1: archaeal RNase HI can cleave an RNA-DNA junction. Biochem J. 2004 Aug 1;381(Pt 3):795-802. PMID:15115438 doi:http://dx.doi.org/10.1042/BJ20040153

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OCA

[1] Ohtani N, Yanagawa H, Tomita M, Itaya M. Identification of the first archaeal Type 1 RNase H gene from Halobacterium sp. NRC-1: archaeal RNase HI can cleave an RNA-DNA junction. Biochem J. 2004 Aug 1;381(Pt 3):795-802. PMID:15115438 doi:http://dx.doi.org/10.1042/BJ20040153

[1]

4e19

Crystal structure of RNase H1 from halophilic archaeon Halobacterium salinarum NRC-1Crystal structure of RNase H1 from halophilic archaeon Halobacterium salinarum NRC-1

Structural highlights

Function

See Also

References

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4e19

Crystal structure of RNase H1 from halophilic archaeon Halobacterium salinarum NRC-1Crystal structure of RNase H1 from halophilic archaeon Halobacterium salinarum NRC-1

Structural highlights

Function

See Also

References

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