3zon
Human TYK2 pseudokinase domain bound to a kinase inhibitorHuman TYK2 pseudokinase domain bound to a kinase inhibitor
DiseaseDisease
[TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
FunctionFunction
[TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.[1]
About this StructureAbout this Structure
3zon is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.