4ibx
Crystal structure of stabilized TEM-1 beta-lactamase variant v.13Crystal structure of stabilized TEM-1 beta-lactamase variant v.13
FunctionFunction
[BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
About this StructureAbout this Structure
4ibx is a 5 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.