Antithrombin

Antithrombin (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interaction of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation.

3D structures of antithrombin3D structures of antithrombin

Updated January 2013

1att – AT-III – bovine

1ant, 2ant – hAT – human

1e05 - hα-AT-III

1e04 – hβ-AT-III

1ath, 2znh, 4eb1 – hAT-III

1dzg, 1oyh, 1t1f, 2beh, 2b4x, 2hij - hAT-III (mutant)

Antithrombin binary complexesAntithrombin binary complexes

1azx, 1nq9, 3evj – hAT + heparin pentasaccharide

1e03 – hα-AT-III + heparin pentasaccharide

1dzh - hAT-III (mutant) + fluorescein

2gd4 - hAT-III (mutant) + coagulation factor X

1br8, 1jvq, 1lk6, 1r1l – hAT-III + peptide

Antithrombin ternary complexesAntithrombin ternary complexes

1sr5 - hAT-III + prothrombin + heparin heptasaccharide

1tb6 - hAT-III (mutant) + thrombin + heparin polysaccharide

2b5t - AT-III (mutant) + thrombin (mutant) + heparin polysaccharide

3kcg - hAT-III (mutant) + coagulation factor IXa + heparin pentasaccharide