2ymn

Organization of the Influenza Virus Replication MachineryOrganization of the Influenza Virus Replication Machinery

Structural highlights 2ymn is a 6 chain structure with sequence from Influenza a virus (a/puerto rico/8/1934(h1n1)). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Influenza virus ribonucleoprotein complexes (RNPs) are central to the viral life cycle and in adaptation to new host species. RNPs are composed of the viral genome, viral polymerase, and many copies of the viral nucleoprotein. In vitro cell expression of all RNP protein components with four of the eight influenza virus gene segments enabled structural determination of native influenza virus RNPs by means of cryogenic electron microscopy (cryo-EM). The cryo-EM structure reveals the architecture and organization of the native RNP, defining the attributes of its largely helical structure and how polymerase interacts with nucleoprotein and the viral genome. Observations of branched-RNP structures in negative-stain electron microscopy and their putative identification as replication intermediates suggest a mechanism for viral replication by a second polymerase on the RNP template. Organization of the influenza virus replication machinery.,Moeller A, Kirchdoerfer RN, Potter CS, Carragher B, Wilson IA Science. 2012 Dec 21;338(6114):1631-4. doi: 10.1126/science.1227270. Epub 2012, Nov 22. PMID:23180774 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Nucleoprotein

spinqualitylabelsall models 2ymn, resolution 20.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image