3dyd
Human Tyrosine AminotransferaseHuman Tyrosine Aminotransferase
DiseaseDisease
[ATTY_HUMAN] Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:276600]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.[1]
FunctionFunction
[ATTY_HUMAN] Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.[2][3]
About this StructureAbout this Structure
3dyd is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Natt E, Kida K, Odievre M, Di Rocco M, Scherer G. Point mutations in the tyrosine aminotransferase gene in tyrosinemia type II. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9297-301. PMID:1357662
- ↑ Seralini GE, Luu-The V, Labrie F. Cloning and expression of human tyrosine aminotransferase cDNA. Biochim Biophys Acta. 1995 Jan 2;1260(1):97-101. PMID:7999802
- ↑ Sivaraman S, Kirsch JF. The narrow substrate specificity of human tyrosine aminotransferase--the enzyme deficient in tyrosinemia type II. FEBS J. 2006 May;273(9):1920-9. PMID:16640556 doi:10.1111/j.1742-4658.2006.05202.x
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Homo sapiens
- Tyrosine transaminase
- Andersson, J.
- Arrowsmith, C H.
- Berg, S Van Den.
- Berglund, H.
- Collins, R.
- Dahlgren, L G.
- Edwards, A M.
- Flodin, S.
- Flores, A.
- Graslund, S.
- Hammarstrom, M.
- Johansson, A.
- Johansson, I.
- Karlberg, T.
- Kotenyova, T.
- Lehtio, L.
- Moche, M.
- Nilsson, M E.
- Nordlund, P.
- Nyman, T.
- Olesen, K.
- Persson, C.
- SGC, Structural Genomics Consortium.
- Sagemark, J.
- Schuler, H.
- Thorsell, A G.
- Tresaugues, L.
- Weigelt, J.
- Welin, M.
- Wikstrom, M.
- Wisniewska, M.
- Aminotransferase
- Disease mutation
- Phenylalanine catabolism
- Plp
- Pyridoxal phosphate
- Sgc
- Structural genomic
- Structural genomics consortium
- Transferase
- Tyrosine
- Tyrosine catabolism