4ie2
Crystal structure of human Arginase-2 complexed with inhibitor 1hCrystal structure of human Arginase-2 complexed with inhibitor 1h
Template:ABSTRACT PUBMED 23453840
FunctionFunction
[ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
About this StructureAbout this Structure
4ie2 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Arginase
- Homo sapiens
- Andreoli, M.
- Beckett ,P.
- Cousido-Siah, A.
- Golebiowski, A.
- Jagdmann, E.
- Ji, M K.
- Mazur, A.
- Mitschler, A.
- Padmanilayam, M.
- Podjarny, A.
- Ruiz, F X.
- Ryder, T.
- Schroeter, H.
- Whitehouse, D.
- Zandt, M C.Van.
- Alpha/beta fold
- Arginine metabolism
- Hydrolase
- Hydrolase-hydrolase inhibitor complex
- Manganese
- Metalloenzyme
- Mitochondrion