CRYSTAL STRUCTURES OF THE B-FORM DNA-RNA CHIMER (5'-D(*IP*)-R(*CP*)-D(*IP*)-R(*CP*)-D(*IP*CP*IP*C)-3') COMPLEXED WITH DISTAMYCINCRYSTAL STRUCTURES OF THE B-FORM DNA-RNA CHIMER (5'-D(*IP*)-R(*CP*)-D(*IP*)-R(*CP*)-D(*IP*CP*IP*C)-3') COMPLEXED WITH DISTAMYCIN

Structural highlights

217d is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
NonStd Res:
Resources:FirstGlance, OCA, RCSB, PDBsum

Publication Abstract from PubMed

Two DNA-RNA chimers, complexed with DNA minor groove binding drugs, have been observed to adopt the B-form conformation for the first time. Thus, the RNA duplex may assume the B-DNA conformation when interacting with drugs, peptides or proteins.

Crystal structures of B-form DNA-RNA chimers complexed with distamycin.,Chen X, Ramakrishnan B, Sundaralingam M Nat Struct Biol. 1995 Sep;2(9):733-5. PMID:7552741[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. Chen X, Ramakrishnan B, Sundaralingam M. Crystal structures of B-form DNA-RNA chimers complexed with distamycin. Nat Struct Biol. 1995 Sep;2(9):733-5. PMID:7552741

217d, resolution 1.70Å

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