1brp
CRYSTAL STRUCTURE OF THE TRIGONAL FORM OF HUMAN PLASMA RETINOL-BINDING PROTEIN AT 2.5 ANGSTROMS RESOLUTIONCRYSTAL STRUCTURE OF THE TRIGONAL FORM OF HUMAN PLASMA RETINOL-BINDING PROTEIN AT 2.5 ANGSTROMS RESOLUTION
Template:ABSTRACT PUBMED 8464067
DiseaseDisease
[RET4_HUMAN] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
FunctionFunction
[RET4_HUMAN] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
About this StructureAbout this Structure
1brp is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Zanotti G, Ottonello S, Berni R, Monaco HL. Crystal structure of the trigonal form of human plasma retinol-binding protein at 2.5 A resolution. J Mol Biol. 1993 Mar 20;230(2):613-24. PMID:8464067 doi:http://dx.doi.org/10.1006/jmbi.1993.1173