3d8z

RNase A- 5'-Deoxy-5'-N-pyrrolidinothymidine complexRNase A- 5'-Deoxy-5'-N-pyrrolidinothymidine complex

Template:ABSTRACT PUBMED 19173562

FunctionFunction

[RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.^[1]

About this StructureAbout this Structure

3d8z is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Samanta A, Leonidas DD, Dasgupta S, Pathak T, Zographos SE, Oikonomakos NG. Morpholino, Piperidino, and Pyrrolidino Derivatives of Pyrimidine Nucleosides as Inhibitors of Ribonuclease A: Synthesis, Biochemical, and Crystallographic Evaluation (#) (,) (dagger). J Med Chem. 2009 Jan 27. PMID:19173562 doi:10.1021/jm800724t

↑ delCardayre SB, Ribo M, Yokel EM, Quirk DJ, Rutter WJ, Raines RT. Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11. Protein Eng. 1995 Mar;8(3):261-73. PMID:7479688

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OCA

[2] Samanta A, Leonidas DD, Dasgupta S, Pathak T, Zographos SE, Oikonomakos NG. Morpholino, Piperidino, and Pyrrolidino Derivatives of Pyrimidine Nucleosides as Inhibitors of Ribonuclease A: Synthesis, Biochemical, and Crystallographic Evaluation (#) (,) (dagger). J Med Chem. 2009 Jan 27. PMID:19173562 doi:10.1021/jm800724t

[1] Cardayre SB, Ribo M, Yokel EM, Quirk DJ, Rutter WJ, Raines RT. Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11. Protein Eng. 1995 Mar;8(3):261-73. PMID:7479688

[1]

[xtra 1]