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3qi3

Revision as of 09:18, 13 November 2013 by OCA (talk | contribs)

Template:STRUCTURE 3qi3

Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691

Template:ABSTRACT PUBMED 21483814

FunctionFunction

[PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.[1]

About this StructureAbout this Structure

3qi3 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1]

  1. ↑ Hou J, Xu J, Liu M, Zhao R, Luo HB, Ke H. Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic Acid, and role of the invariant glutamine. PLoS One. 2011 Mar 31;6(3):e18092. PMID:21483814 doi:10.1371/journal.pone.0018092
  1. ↑ Liu S, Mansour MN, Dillman KS, Perez JR, Danley DE, Aeed PA, Simons SP, Lemotte PK, Menniti FS. Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13309-14. Epub 2008 Aug 29. PMID:18757755

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