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| 1i10, resolution 2.30Å ()
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| Ligands:
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, ,
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| Gene:
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LDHA (Homo sapiens)
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| Activity:
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L-lactate dehydrogenase, with EC number 1.1.1.27
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| Related:
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1i0z, 9ldt, 5ldh, 1ldg
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| Structural annotation:
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| Resources:
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CATH : 1I10A02, 1I10A01, 1I10B01, 1I10B02, 1I10C02, 1I10C01, 1I10D01, 1I10D02, 1I10E02, 1I10E01, 1I10F01, 1I10F02, 1I10G02, 1I10G01, 1I10H01, 1I10H02
InterPro : Ipr001557, Ipr001236, Ipr011304
Pfam : PF00056, PF02866
SCOP : d1i10a1, d1i10a2, d1i10b2, d1i10b1, d1i10c2, d1i10c1, d1i10d1, d1i10d2, d1i10e1, d1i10e2, d1i10f1, d1i10f2, d1i10g2, d1i10g1, d1i10h2, d1i10h1
UniProt : P00338
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| Resources:
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FirstGlance, OCA, RCSB, PDBsum
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| Coordinates:
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save as pdb, mmCIF, xml
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HUMAN MUSCLE L-LACTATE DEHYDROGENASE M CHAIN, TERNARY COMPLEX WITH NADH AND OXAMATEHUMAN MUSCLE L-LACTATE DEHYDROGENASE M CHAIN, TERNARY COMPLEX WITH NADH AND OXAMATE
Template:ABSTRACT PUBMED 11276087
DiseaseDisease
[LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.[1]
About this StructureAbout this Structure
1i10 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
[xtra 1]
- ↑ Read JA, Winter VJ, Eszes CM, Sessions RB, Brady RL. Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. Proteins. 2001 May 1;43(2):175-85. PMID:11276087
- ↑ Maekawa M, Sudo K, Kanno T, Li SS. Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency. Biochem Biophys Res Commun. 1990 Apr 30;168(2):677-82. PMID:2334430
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OCA
