2spc

CRYSTAL STRUCTURE OF THE REPETITIVE SEGMENTS OF SPECTRINCRYSTAL STRUCTURE OF THE REPETITIVE SEGMENTS OF SPECTRIN

Structural highlights 2spc is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The elongated proteins of the spectrin family (dystrophin, alpha-actinin, and spectrin) contain tandemly repeated segments and form resilient cellular meshworks by cross-linking actin filaments. The structure of one of the repetitive segments of alpha-spectrin was determined at a 1.8 angstrom resolution. A segment consists of a three-helix bundle. A model of the interface between two tandem segments suggests that hydrophobic interactions between segments may constrain intersegment flexibility. The helix side chain interactions explain how mutations that are known to produce hemolytic anemias disrupt spectrin associations that sustain the integrity of the erythrocyte membrane. Crystal structure of the repetitive segments of spectrin.,Yan Y, Winograd E, Viel A, Cronin T, Harrison SC, Branton D Science. 1993 Dec 24;262(5142):2027-30. PMID:8266097 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Spectrin

spinqualitylabelsall models 2spc, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image