Eukaryotic initiation factor

Eukaryotic initiation factors (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG.

3D structures of eukaryotic initiation factor3D structures of eukaryotic initiation factor

EIF1EIF1

2if1, 1d7q – hEIF1 – human – NMR
2ogh - yEIF1 – NMR

EIF2EIF2

1kl9 – hEIF2A
1q8x – hEIF2A - NMR
1si2, 1si3, 4ei3, 4f3t – hEIF2C PAZ domain + DNA
3luk - hEIF2C MID domain
3lud, 3lug, 3luh, 3luj, 3qx8, 3qx9 - hEIF2C MID domain + nucleotide
1q46 – yEIF2A – yeast
2a19, 2a1a – yEIF2A (mutant) + interferon-induced protein kinase
3ecs – hEIF2B

EIF3EIF3

2nlw - hEIF3B RNA recognition domain – NMR
3ns5, 3ns6 - yEIF3B RNA recognition domain
2krb - hEIF3B RNA recognition domain + hEIF3J peptide
2cq0 – hEIF3G RNA recognition domain – NMR
3zwl - yEIF3I + EIF3B C terminal
3bpj – hEIF3J
1rz4 – hEIF3K

EIF4EIF4

1fuk – yEIF4A C terminal
1fuu - yEIF4A mRNA helicase domain
2g9n, 3bor – hEIF4A DEAD domain
3ex7, 2xb2 – hEIF4A + MAGO homolog + RNA-binding protein 8A + CASC3 + RNA
2zu6, 3eiq – hEIF4A + programmed cell death protein
1wi8, 2j76 – hEIF4B RNA recognition domain - NMR
1ejh – mEIF4E + EIF4G peptide + GDP – mouse
1ej1, 1l8b - mEIF4E + nucleotide
2gpq, 3tf2 – hEIF4E
2wmc - EIF4E - pea
2idr – wEIF4E – wheat
2idv - wEIF4E (mutant) + GDP
1ipb, 1ipc - hEIF4E + nucleotide
4dt6, 4dum – hEIF4E + inhibitor
2w97 – hEIF4E + hEIF4G peptide
1wkw - hEIF4E + EIF4E-binding protein peptide + GDP
2v8w, 2v8x, 2v8y, 3u7x - hEIF4E + EIF4E-binding protein peptide
3am7 - hEIF4E + EIF4E-binding protein peptide + nucleotide
1ej4 - mEIF4E + EIF4E-binding protein peptide
3hxg, 3hxi - EIF4E + EIF4E-binding protein peptide + GDP – Schistosoma mansoni
3m93, 3m94 - EIF4E + EIF4E-binding protein peptide + nucleotide – Pig roundworm
1ap8 – yEIF4E + GDP – NMR
1rf8 - yEIF4E + yEIF4GI peptide + GDP
2vso, 2vsx - yEIF4E + yEIF4F
3l6a - hEIF4GII C terminal
1ug3 – hEIF4GI C terminal (mutant)
1hu3, 3d3m – hEIF4GII middle domain
2dng – hEIF4H RNA recognition domain – NMR

EIF5EIF5

1eif, 2eif – EIF5A – Methanocaldococcus janaschii
1x6o – EIF5A – Leishmania braziliensis
1xtd - EIF5A – Leishmania mexicana
3hks – EIF5A – Arabidopsis thaliana
3cpf - hEIF
2ful – yEIF5 C terminal
2iu1 - hEIF5 C terminal
2g2k – hEIF5 N terminal (mutant) – NMR
2e9h – hEIF5 – NMR
3cpf – hEIF5A
3er0 - yEIF5A

EIF6EIF6

1g62 – yEIF6
2x7n – yEIF6S + sarcin-ricin loop + ribosomal protein L23 + ribosomal protein L24