2vtp
IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN.IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN.
Template:ABSTRACT PUBMED 18656911
About this StructureAbout this Structure
2vtp is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Wyatt PG, Woodhead AJ, Berdini V, Boulstridge JA, Carr MG, Cross DM, Davis DJ, Devine LA, Early TR, Feltell RE, Lewis EJ, McMenamin RL, Navarro EF, O'Brien MA, O'Reilly M, Reule M, Saxty G, Seavers LC, Smith DM, Squires MS, Trewartha G, Walker MT, Woolford AJ. Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design. J Med Chem. 2008 Aug 28;51(16):4986-99. Epub 2008 Jul 26. PMID:18656911 doi:10.1021/jm800382h
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OCACategories:
- Pages with broken file links
- Homo sapiens
- Berdini, V.
- Boulstridge, J A.
- Brien, M A.O.
- Carr, M G.
- Cross, D M.
- Danillon, D.
- Davis, D J.
- Devine, L A.
- Early, T R.
- Feltell, R E.
- Lewis, E J.
- Mcmenamin, R L.
- Navarro, E F.
- Reilly, M O.
- Reule, M.
- Saxty, G.
- Seavers, L C.A.
- Smith, D.
- Squires, M S.
- Trewartha, G.
- Walker, M T.
- Woodhead, A J.
- Woolford, A J.
- Wyatt, P G.
- Cell cycle
- Mitosis
- Serine/threonine protein kinase
- Transferase