Eric Martz's Favorites

Eric Martz's FavoritesEric Martz's Favorites

• 1995-1997: Recoverin, a calcium-activated myristoyl switch. Calcium induces this protein to undergo a huge conformational change, literally turning one domain inside out. The N-terminal myristic acid goes from being buried within the hydrophobic core of a protein domain to being exposed, facilitating the attachment of this enzyme to disc membranes in rod cells in the eye. Morphs of this transition are shown.
• 2006 - Tamiflu bound to avian influenza neuraminidase N1, 2hu4 has tamiflu bound, while 2hty lacks this ligand. Tamiflu was designed for N2/N9, not N1. Its antiviral activity via N1 is fortunate but surprising. Comparison of these two structures shows that tamiflu pulls N1 loop 147-152 into close contact, a case of "induced fit". Another surprise was a cavity near tamiflu that could serve as a target for designing better anti-avian influenza drugs.
  • More background.
  • Lesson plan on this topic.
  • Morphs of the induced fit.
  • Cavity near tamiflu is shown nicely in View 2 of this chapter in a tutorial about developing tutorials using Jmol.

To be added: MHC class I; domain-switched antibody; flagellar hook; dna-binding morph.