2i6z
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X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme
OverviewOverview
The interactions of cisplatin and its analogues, transplatin, carboplatin, and oxaliplatin, with hen egg white lysozyme were analysed through ESI, mass spectrometry, and the resulting metallodrug-protein adducts, identified; the X-ray crystal structure of the cisplatin lysozyme, derivative, solved at 1.9 A resolution, reveals selective platination of, imidazole Nepsilon of His15.
About this StructureAbout this Structure
2I6Z is a Single protein structure of sequence from Gallus gallus with , and as ligands. Active as Lysozyme, with EC number 3.2.1.17 Known structural/functional Sites: , and . Full crystallographic information is available from OCA.
ReferenceReference
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme., Casini A, Mastrobuoni G, Temperini C, Gabbiani C, Francese S, Moneti G, Supuran CT, Scozzafava A, Messori L, Chem Commun (Camb). 2007 Jan 14;(2):156-8. Epub 2006 Oct 26. PMID:17180231
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