4a3p

STRUCTURE OF USP15 DUSP-UBL DELETION MUTANTSTRUCTURE OF USP15 DUSP-UBL DELETION MUTANT

Structural highlights

4a3p is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	1w6v, 4a3o
Activity:	Ubiquitinyl hydrolase 1, with EC number 3.4.19.12
Resources:	FirstGlance, OCA, RCSB, PDBsum

Publication Abstract from PubMed

USP4, 11 and 15 are three closely related paralogues of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. The DUSP domain and the UBL domain in these proteins are juxtaposed which may provide a functional unit conferring specificity. We determined the structures of the USP15 DUSP-UBL double domain unit in monomeric and dimeric states. We then conducted comparative analysis of the structural and physical properties of all three DUSP-UBL units. We identified structural features that dictate different dispositions between constituent domains, which in turn may influence respective binding properties. Structured summary of protein interactions: USP15 and USP15bind by molecular sieving (View Interaction: 1, 2) USP15 and USP15physically interact by molecular sieving (View interaction) USP4 and USP4bind by molecular sieving (View Interaction: 1, 2) USP15 and USP15bind by X ray scattering (View interaction) USP11 and USP11bind by molecular sieving (View interaction) USP4 and USP4bind by nuclear magnetic resonance (View interaction) USP15 and USP15bind by X-ray crystallography (View interaction).

Structural variability of the ubiquitin specific protease DUSP-UBL double domains.,Elliott PR, Liu H, Pastok MW, Grossmann GJ, Rigden DJ, Clague MJ, Urbe S, Barsukov IL FEBS Lett. 2011 Nov 4;585(21):3385-90. Epub 2011 Oct 10. PMID:22001210^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Elliott PR, Liu H, Pastok MW, Grossmann GJ, Rigden DJ, Clague MJ, Urbe S, Barsukov IL. Structural variability of the ubiquitin specific protease DUSP-UBL double domains. FEBS Lett. 2011 Nov 4;585(21):3385-90. Epub 2011 Oct 10. PMID:22001210 doi:10.1016/j.febslet.2011.09.040

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OCA

[1] Elliott PR, Liu H, Pastok MW, Grossmann GJ, Rigden DJ, Clague MJ, Urbe S, Barsukov IL. Structural variability of the ubiquitin specific protease DUSP-UBL double domains. FEBS Lett. 2011 Nov 4;585(21):3385-90. Epub 2011 Oct 10. PMID:22001210 doi:10.1016/j.febslet.2011.09.040

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