1cwo
HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN
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OverviewOverview
The crystal structure of (Thr2, Leu5, d-Hiv8, Leu10)-cyclosporin (cyclic, peptolide SDZ 214-103) has been determined as the unbound crystal form and, as a complex with human cyclophilin A. This pair of structures provides an, example of a significant difference in conformation between free and bound, ligand in crystals. The conformation of the unbound form is unlike that of, both free and bound conformations of cyclosporin A (with the amide bond, between residues 3 and 4 in the cis conformation), while the bound, conformation is similar to that of CsA bound to cyclophilin. The, cyclophilin-bound conformations of both ligands are similar, though this, involves a significantly different waterellipsisligand hydrogen-bonding, structure, which compensates for the chemical differences between the two, ligands.
About this StructureAbout this Structure
1CWO is a Single protein structure of sequence from Homo sapiens. Active as Peptidylprolyl isomerase, with EC number 5.2.1.8 Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Conformational differences of an immunosuppressant peptolide in a single crystal and in a crystal complex with human cyclophilin A., Mikol V, Taylor P, Kallen J, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):451-61. PMID:9769217
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