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CDK Inhibitor p19INK4dCDK Inhibitor p19INK4d

spinqualitylabelsall models PDB ID 1bd8 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1bd8, resolution 1.80Å ()
Structural annotation: Resources: CATH : 1Bd8000 InterPro : Ipr002110 Pfam : PF00023 SCOP : d1bd8__ UniProt : P55273
Functional annotation: Cellular component: cytoplasm nucleus Biological process: regulation of cyclin-dependent protein kinase activity negative regulation of cell cycle cell cycle arrest cell cycle negative regulation of cell proliferation sensory perception of sound Molecular function: cyclin-dependent protein kinase inhibitor activity protein binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

p19 in the Cell Cyclep19 in the Cell Cycle

CDK Inhibitor p19INK4d is a cyclin-dependent kinase (CDK) inhibitor in the INK4 family of CDK inhibitors. Progression through the G1 phase of the cell cycle and subsequent entry into the S phase depend on the phosphorylating effects of CDK4 and CDK6. These two CDKs must form cyclin-CDK complexes to phosphorylate the retinoblastoma protein, inhibiting its growth-suppressing function, and triggering an E2F-dependent transcriptional program necessary for entry into S phase.