1h72: Difference between revisions
New page: left|200px<br /> <applet load="1h72" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h72, resolution 1.8Å" /> '''CRYSTAL STRUCTURE OF... |
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==About this Structure== | ==About this Structure== | ||
1H72 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Methanococcus_jannaschii Methanococcus jannaschii]] with HSE, ANP and TRS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.39 2.7.1.39]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H72 OCA]]. | 1H72 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Methanococcus_jannaschii Methanococcus jannaschii]] with HSE, ANP and TRS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferase Transferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.39 2.7.1.39]]. Structure known Active Sites: ANP, HSE and TRS. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H72 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
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Revision as of 09:26, 30 October 2007
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CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH HSE
OverviewOverview
Homoserine kinase (HSK), the fourth enzyme in the aspartate pathway of, amino acid biosynthesis, catalyzes the phosphorylation of L-homoserine, (Hse) to L-homoserine phosphate, an intermediate in the production of, L-threonine, L-isoleucine, and in higher plants, L-methionine. The, high-resolution structures of Methanococcus jannaschii HSK ternary, complexes with its amino acid substrate and ATP analogues have been, determined by X-ray crystallography. These structures reveal the, structural determinants of the tight and highly specific binding of Hse, which is coupled with local conformational changes that enforce the, sequestration of the substrate. The delta-hydroxyl group of bound Hse is, only 3.4 A away from the gamma-phosphate of the bound nucleotide, poised, for the in-line attack ... [(full description)]
About this StructureAbout this Structure
1H72 is a [Single protein] structure of sequence from [Methanococcus jannaschii] with HSE, ANP and TRS as [ligands]. Active as [Transferase], with EC number [2.7.1.39]. Structure known Active Sites: ANP, HSE and TRS. Full crystallographic information is available from [OCA].
ReferenceReference
Structural basis for the catalysis and substrate specificity of homoserine kinase., Krishna SS, Zhou T, Daugherty M, Osterman A, Zhang H, Biochemistry. 2001 Sep 11;40(36):10810-8. PMID:11535056
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