Selenocysteine: Difference between revisions
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Sec differs from the [[Amino Acids|20 standard amino acids]] because, in all domains of life, it lacks its own tRNA synthetase, and is synthesized from Ser covalently linked to tRNA<sup>Sec</sup>. | Sec differs from the [[Amino Acids|20 standard amino acids]] because, in all domains of life, it lacks its own tRNA synthetase, and is synthesized from Ser covalently linked to tRNA<sup>Sec</sup>. | ||
The [[X-ray crystallography|crystal]] structure of the complex that converts Ser-tRNA<sup>Sec</sup> to Sec-tRNA<sup>Sec</sup> ('''[[3hl2]]''') was reported in 2009<ref name='Palioura'>PMID: 19608919</ref>. This consists of ''O''-Phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS) complexed to tRNA<sup>Sec</sup>, phosphoserine, and thiophosphate. The authors conclude that this structure, together with | The [[X-ray crystallography|crystal]] structure of the complex that converts Ser-tRNA<sup>Sec</sup> to Sec-tRNA<sup>Sec</sup> ('''[[3hl2]]''') was reported in 2009<ref name='Palioura'>PMID: 19608919</ref>. This consists of ''O''-Phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS) complexed to tRNA<sup>Sec</sup>, phosphoserine, and thiophosphate. The authors conclude that this structure, together with enzymology, supports a pyridoxal phosphate-dependent mechanism. | ||
==Notes and References== | ==Notes and References== | ||
<references /> | <references /> | ||