1cwi: Difference between revisions
New page: left|200px<br /> <applet load="1cwi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cwi, resolution 1.9Å" /> '''HUMAN CYCLOPHILIN A ... |
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==About this Structure== | ==About this Structure== | ||
1CWI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CWI OCA]]. | 1CWI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Isomerase Isomerase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]]. Structure known Active Site: BIN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CWI OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: complex (isomerase/immunosuppressant)]] | [[Category: complex (isomerase/immunosuppressant)]] | ||
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Revision as of 09:25, 30 October 2007
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HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-(N-METHYL)-D-ALANINE CYCLOSPORIN
OverviewOverview
Eight new X-ray structures of different cyclophilin, A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide, a useful structural database for the analysis of protein-ligand, interactions. The effect of small chemical differences on protein-ligand, hydrogen-bonding, van der Waals interactions and water structure is, presented.
About this StructureAbout this Structure
1CWI is a [Single protein] structure of sequence from [Homo sapiens]. Active as [Isomerase], with EC number [5.2.1.8]. Structure known Active Site: BIN. Full crystallographic information is available from [OCA].
ReferenceReference
X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A., Kallen J, Mikol V, Taylor P, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):435-49. PMID:9769216
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