1cwo: Difference between revisions
New page: left|200px<br /> <applet load="1cwo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cwo, resolution 1.86Å" /> '''HUMAN CYCLOPHILIN A... |
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==About this Structure== | ==About this Structure== | ||
1CWO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CWO OCA]]. | 1CWO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Isomerase Isomerase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]]. Structure known Active Site: BIN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CWO OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: complex (isomerase/immunosuppressant)]] | [[Category: complex (isomerase/immunosuppressant)]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:30:06 2007'' | ||
Revision as of 09:25, 30 October 2007
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HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN
OverviewOverview
The crystal structure of (Thr2, Leu5, d-Hiv8, Leu10)-cyclosporin (cyclic, peptolide SDZ 214-103) has been determined as the unbound crystal form and, as a complex with human cyclophilin A. This pair of structures provides an, example of a significant difference in conformation between free and bound, ligand in crystals. The conformation of the unbound form is unlike that of, both free and bound conformations of cyclosporin A (with the amide bond, between residues 3 and 4 in the cis conformation), while the bound, conformation is similar to that of CsA bound to cyclophilin. The, cyclophilin-bound conformations of both ligands are similar, though this, involves a significantly different waterellipsisligand hydrogen-bonding, structure, which compensates for the chemical differences between ... [(full description)]
About this StructureAbout this Structure
1CWO is a [Single protein] structure of sequence from [Homo sapiens]. Active as [Isomerase], with EC number [5.2.1.8]. Structure known Active Site: BIN. Full crystallographic information is available from [OCA].
ReferenceReference
Conformational differences of an immunosuppressant peptolide in a single crystal and in a crystal complex with human cyclophilin A., Mikol V, Taylor P, Kallen J, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):451-61. PMID:9769217
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