C-Myc: Difference between revisions
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{{STRUCTURE_c-Myc PDB=2a93 | SCENE= }} | {{STRUCTURE_c-Myc PDB=2a93 | SCENE= }} | ||
The c-Myc | The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc, which is involved in the regulation of the cell cycle. C-Myc belongs to the Myc family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a b-HLH-LZ (basic helix-loop-helix-leucine zipper) protein that must form a heterodimer with another b-HLH-LZ protein, Max, in order to bind DNA and activate transcription. | ||
Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer. | Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer. | ||
Revision as of 23:05, 15 July 2009
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19:45, 15 July 2009 (IDT)Kim Smith==This is a placeholder==
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Template:STRUCTURE c-Myc PDB=2a93
The c-Myc oncogene encodes a transcription factor, c-Myc, which is involved in the regulation of the cell cycle. C-Myc belongs to the Myc family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a b-HLH-LZ (basic helix-loop-helix-leucine zipper) protein that must form a heterodimer with another b-HLH-LZ protein, Max, in order to bind DNA and activate transcription. Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.