User:Tilman Schirmer/Sandbox 204: Difference between revisions
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Overview
Allosteric product binding site
References
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==References== | |||
WspR structure [[3bre]]: | |||
<ref group="xtra">PMID:18366254</ref> | |||
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Revision as of 12:27, 15 July 2009
WspR
OverviewOverview
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from Pseudomonas aeruginosa is a response regulator with an catalytic, diguanylate cyclase, output domain. It is composed of a canonical CheY-like response regulator receiver domain () and a C-terminal domain that confers the catalytic activity with all canonical present.
Although not modified (i.e. phosphorylated) at the active Asp (), the Rec domains mediate formation of WspR. Two dimers, in turn, are associated by head-to-head contact to a of approximate 222 (D2) symmetry.
Allosteric product binding siteAllosteric product binding site
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There are two allosteric sites ( and ) that become cross-linked by (c-di-GMP)2 dimers in the molecule. For a close-up click (, , ). Note that there are four (c-di-GMP)2 dimers per WspR tetramer.
ReferencesReferences
- ↑ De N, Pirruccello M, Krasteva PV, Bae N, Raghavan RV, Sondermann H. Phosphorylation-independent regulation of the diguanylate cyclase WspR. PLoS Biol. 2008 Mar 25;6(3):e67. PMID:18366254 doi:10.1371/journal.pbio.0060067