3dy7: Difference between revisions

Revision as of 10:23, 17 June 2009

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File:3dy7.jpg

Template:STRUCTURE 3dy7

X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATPX-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP

Template:ABSTRACT PUBMED 19019675

About this StructureAbout this Structure

3DY7 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}^{[xtra 2]}

↑ Tecle H, Shao J, Li Y, Kothe M, Kazmirski S, Penzotti J, Ding YH, Ohren J, Moshinsky D, Coli R, Jhawar N, Bora E, Jacques-O'Hagan S, Wu J. Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg Med Chem Lett. 2009 Jan 1;19(1):226-9. Epub 2008 Oct 31. PMID:19019675 doi:10.1016/j.bmcl.2008.10.108
↑ Ohren JF, Chen H, Pavlovsky A, Whitehead C, Zhang E, Kuffa P, Yan C, McConnell P, Spessard C, Banotai C, Mueller WT, Delaney A, Omer C, Sebolt-Leopold J, Dudley DT, Leung IK, Flamme C, Warmus J, Kaufman M, Barrett S, Tecle H, Hasemann CA. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7. Epub 2004 Nov 14. PMID:15543157 doi:10.1038/nsmb859

Page seeded by OCA on Wed Jun 17 10:23:11 2009

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OCA

[1] Tecle H, Shao J, Li Y, Kothe M, Kazmirski S, Penzotti J, Ding YH, Ohren J, Moshinsky D, Coli R, Jhawar N, Bora E, Jacques-O'Hagan S, Wu J. Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg Med Chem Lett. 2009 Jan 1;19(1):226-9. Epub 2008 Oct 31. PMID:19019675 doi:10.1016/j.bmcl.2008.10.108

[2] Ohren JF, Chen H, Pavlovsky A, Whitehead C, Zhang E, Kuffa P, Yan C, McConnell P, Spessard C, Banotai C, Mueller WT, Delaney A, Omer C, Sebolt-Leopold J, Dudley DT, Leung IK, Flamme C, Warmus J, Kaufman M, Barrett S, Tecle H, Hasemann CA. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7. Epub 2004 Nov 14. PMID:15543157 doi:10.1038/nsmb859

[xtra 1]

[xtra 2]

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-'''Unreleased structure'''
+{{Seed}}
+[[Image:3dy7.jpg|left|200px]]
-The entry 3dy7 is ON HOLD  until Paper Publication
+<!--
+The line below this paragraph, containing "STRUCTURE_3dy7", creates the "Structure Box" on the page.
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+or leave the SCENE parameter empty for the default display.
+-->
+{{STRUCTURE_3dy7|  PDB=3dy7  |  SCENE=  }}
-Authors: Ohren, J.F., Pavlovsky, A., Zhang, E.
+===X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP===
-Description: X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:27:24 2008''
+<!--
+The line below this paragraph, {{ABSTRACT_PUBMED_19019675}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 19019675 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_19019675}}
+==About this Structure==
+DY7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DY7 OCA].
+==Reference==
+<ref group="xtra">PMID:19019675</ref><ref group="xtra">PMID:15543157</ref><references group="xtra"/>
+[[Category: Homo sapiens]]
+[[Category: Mitogen-activated protein kinase kinase]]
+[[Category: Ohren, J F.]]
+[[Category: Pavlovsky, A.]]
+[[Category: Zhang, E.]]
+[[Category: Acetylation]]
+[[Category: Atp-binding]]
+[[Category: Atp-bound protein kinase]]
+[[Category: Disease mutation]]
+[[Category: Dual specificity protein kinase]]
+[[Category: Inhibitor-bound protein kinase]]
+[[Category: Non-atp-competitive kinase inhibitor]]
+[[Category: Nucleotide-binding]]
+[[Category: Phosphoprotein]]
+[[Category: Serine/threonine-protein kinase]]
+[[Category: Transferase]]
+[[Category: Tyrosine-protein kinase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 10:23:11 2009''