1boy: Difference between revisions
New page: left|200px<br /> <applet load="1boy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1boy, resolution 2.2Å" /> '''EXTRACELLULAR REGION... |
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==About this Structure== | ==About this Structure== | ||
1BOY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BOY OCA]]. | 1BOY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Structure known Active Sites: 7A1, 7A2 and XA1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BOY OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: initiator of blood coagulation in vertebrates]] | [[Category: initiator of blood coagulation in vertebrates]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:24:33 2007'' | ||
Revision as of 09:19, 30 October 2007
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EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR
OverviewOverview
Tissue factor is a cell-surface glycoprotein receptor which initiates the, blood coagulation cascade after vessel injury by interacting with blood, clotting factor VII/VIIa and which is implicated in various pathological, processes. When bound to tissue factor, factor VII is readily converted to, the active protease factor VIIa by trace amounts of factors Xa, IXa or, VIIa. Human tissue factor consists of 263 residues, the first 219 of which, comprise the extracellular region. We have determined the crystal, structure of the extracellular region at a resolution of 2.2 A. Tissue, factor consists of two immunoglobulin-like domains associated through an, extensive, novel, interdomain interface region. The binding site for, factor VII lies at the interface region and involves residues from ... [(full description)]
About this StructureAbout this Structure
1BOY is a [Single protein] structure of sequence from [Homo sapiens]. Structure known Active Sites: 7A1, 7A2 and XA1. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of the extracellular region of human tissue factor., Harlos K, Martin DM, O'Brien DP, Jones EY, Stuart DI, Polikarpov I, Miller A, Tuddenham EG, Boys CW, Nature. 1994 Aug 25;370(6491):662-6. PMID:8065454
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