2bo7: Difference between revisions
New page: left|200px<br /> <applet load="2bo7" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bo7, resolution 2.95Å" /> '''DISSECTION OF MANNO... |
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==About this Structure== | ==About this Structure== | ||
2BO7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rhodothermus_marinus Rhodothermus marinus]] with CO and GDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BO7 OCA]]. | 2BO7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rhodothermus_marinus Rhodothermus marinus]] with CO and GDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BO7 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: structure]] | [[Category: structure]] | ||
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Revision as of 09:19, 30 October 2007
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DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE
OverviewOverview
The enzymatic transfer of activated mannose yields mannosides in, glycoconjugates and oligo- and polysaccharides. Yet, despite its, biological necessity, the mechanism by which glycosyltransferases, recognize mannose and catalyze its transfer to acceptor molecules is, poorly understood. Here, we report broad high-throughput screening and, kinetic analyses of both natural and synthetic substrates of Rhodothermus, marinus mannosylglycerate synthase (MGS), which catalyzes the formation of, the stress protectant 2-O-alpha-D-mannosyl glycerate. The sequence of MGS, indicates that it is at the cusp of inverting and retaining transferases., The structures of apo MGS and complexes with donor and acceptor molecules, including GDP-mannose, combined with mutagenesis of the binding and, catalytic ... [(full description)]
About this StructureAbout this Structure
2BO7 is a [Single protein] structure of sequence from [Rhodothermus marinus] with CO and GDP as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structural dissection and high-throughput screening of mannosylglycerate synthase., Flint J, Taylor E, Yang M, Bolam DN, Tailford LE, Martinez-Fleites C, Dodson EJ, Davis BG, Gilbert HJ, Davies GJ, Nat Struct Mol Biol. 2005 Jul;12(7):608-14. Epub 2005 Jun 12. PMID:15951819
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