2enr: Difference between revisions
New page: left|200px<br /> <applet load="2enr" size="450" color="white" frame="true" align="right" spinBox="true" caption="2enr, resolution 2.35Å" /> '''CO-CRYSTALS OF DEME... |
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==About this Structure== | ==About this Structure== | ||
2ENR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]] with CD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2ENR OCA]]. | 2ENR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]] with CD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: S1 and S2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2ENR OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: plant lectin]] | [[Category: plant lectin]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:23:09 2007'' | ||
Revision as of 09:18, 30 October 2007
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CO-CRYSTALS OF DEMETALLIZED CONCANAVALIN A WITH CADMIUM HAVING A CADMIUM ION BOUND IN BOTH THE S1 SITE AND THE S2 SITE
OverviewOverview
The crystal structures of cadmium/cadmium and zinc/calcium concanavalin A, (con A) at pH 5.0 and pH 6.15, respectively, were determined. The, structure of cadmium/cadmium con A confirms that the secondary, Cd(2+)-binding site S3 is empty at pH 5. The metal-binding sites S1 and S2, are only very slightly affected by the substitution with cadmium. On the, other hand, S1 and S2 and most of the protein surface of zinc/calcium con, A at pH 6.15 differ from other fully metal-bound and carbohydrate-free, structures. Most of these structural differences at the protein surface, are a result of the interplay between metal binding, protonation and, crystal packing. This interplay is expressed by relative rotations and, translations of the con A units in alternative crystal packings and, ... [(full description)]
About this StructureAbout this Structure
2ENR is a [Single protein] structure of sequence from [Canavalia ensiformis] with CD as [ligand]. Structure known Active Sites: S1 and S2. Full crystallographic information is available from [OCA].
ReferenceReference
Zinc/calcium- and cadmium/cadmium-substituted concanavalin A: interplay of metal binding, pH and molecular packing., Bouckaert J, Loris R, Wyns L, Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1569-76. PMID:11092923
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