Sandbox 72: Difference between revisions

Revision as of 17:10, 1 May 2009

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FIBRINFIBRIN

This protein works in the blood to quickly blocks any damage to the circulatory system, creating a temporary patch that allows time for more permanent repairs. It is a strong protein that is inactive until activated when a cut or lacerition to the skin is present. Fibrin is involved in the following biological processes of humans: Signal transduction, Blood coagulation, Platelet activation, and Protein polymerization .Fibrin is made from fibrinogen, a soluble plasma glycoprotein that is made by the liver. Processes in the coagulation cascade activate the protein : zymogen prothrombin to the serine protease thrombin, which is responsible for converting fibrinogen into fibrin. Fibrin is then cross linked by factor XIII to form a clot.

FUNCTION & STRUCTUREFUNCTION & STRUCTURE

Fibrin in the blood works along with two other molecules. These molecules are platelets (small fragments of blood cells that circulate in the blood), and neighboring blood vessels which constrict when needed. These methods work together along with Fibrin to create scabs which stop the flow of blood. The structure of Fibrin is mainly consists of single alpha helices shown in pink and beta sheets shown in yellow. The of The Fibrin Protein allows it to be flexible and clog lacerations to the skin. Apart of Fibrin, there is a vertebrate hexamer containing two sets of three different chains (α, β, and γ), linked to each other by bonds. Fibrin is more of a crystal structure with two double-d fragment from human fibrin with two bound ligands. The chemical structures of the ligands are Ca+2 ion, alpha-D-mannose (C6H1206), and D-glcosamine (C8H15NO6). This is the of fibrin.

Additional InformationAdditional Information

1m1j, resolution 2.70Å ()

Ligands:

, ,

Related:

1ei3, 1fzc

Structural annotation:
Resources:	CATH : 1M1Ja00, 1M1Jb02, 1M1Jb01, 1M1Jb03, 1M1Jc01, 1M1Jc02, 1M1Jc03, 1M1Jd00, 1M1Je01, 1M1Je03, 1M1Je02, 1M1Jf01, 1M1Jf02, 1M1Jf03 InterPro : Ipr012290, Ipr014716, Ipr014814, Ipr002181, Ipr014715 Pfam : PF08702, PF00147 SCOP : d1m1ja_, d1m1jf1, d1m1jf2 UniProt : P14448, Q02020, O93568

Functional annotation:
Cellular component:	fibrinogen complex
Biological process:	signal transduction blood coagulation platelet activation protein polymerization
Molecular function:	protein binding, bridging receptor binding

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Pat McQuaid, Student

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 == '''FUNCTION & STRUCTURE''' ==
 Fibrin in the blood works along with two other molecules. These molecules are platelets (small fragments of blood cells that circulate in the blood), and neighboring blood vessels which constrict when needed. These methods work together along with Fibrin to create scabs which stop the flow of blood. The structure of Fibrin is mainly consists of single alpha helices shown in pink  and beta sheets shown in yellow. The <scene name='Sandbox_72/Hydrogen_side_chain_bonds/1'>Back Bone</scene> of The Fibrin Protein allows it to be flexible and clog lacerations to the skin. Apart of Fibrin, there is a vertebrate hexamer containing two sets of three different chains (α, β, and γ), linked to each other by <scene name='Sandbox_72/Polar_site/1'>disulfide bonds</scene> bonds.
-Fibrin is more of a crystal structure with two double-d fragment from human fibrin with two bound ligands. The chemical structures of the ligands are Ca+2 ion, alpha-D-mannose (C6H1206), and D-glcosamine (C8H15NO6).
+Fibrin is more of a crystal structure with two double-d fragment from human fibrin with two bound ligands. The chemical structures of the ligands are Ca+2 ion, alpha-D-mannose (C6H1206), and D-glcosamine (C8H15NO6). This is the <scene name='Sandbox_72/Practice/1'>beta sheets</scene> of fibrin.
 == '''Additional Information''' ==