Rebecca Martin/Sandbox1

IgAIgA

IgA1

StructureStructure

• Immunoglobulin Structure

Antibodies are composed of a heavy chain and a light chain.

Fab fragment

• Forms of IgA

Dimeric Structure

spinqualitylabelsall models dimeric Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

• Secretory Component

IgA1 and IgA2IgA1 and IgA2

spinqualitylabelsall models monomeric IgA2 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

spinqualitylabelsall models monomeric IgA1 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

spinqualitylabelsall models secretory Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

spinqualitylabelsall models secretory IgA1 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Secretory ComponentSecretory Component

spinqualitylabelsall models secretory component. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Limitations of the Current StudiesLimitations of the Current Studies

Because of the nature of the IgA molecule, crystalizing this structure was not possible. Therefore, many of these structures are based on models and not actual crystal structures. Because ...., the models were depositable in the PDB. I tried to include other crystallographic data when available, supporting the proposed models- as the authors did in the original papers.

Questions for the FutureQuestions for the Future

Because of the limitating resolution of these models, many details concerning the binding residues and residue interactions are left unknown. Crystallographic structure will yield further insights into the structure of IgA, the interactions between IgA and other molecules, and ....

LinksLinks

IgAIgA

• Monomeric

Model of human IgA1 determined by solution scattering, curve-fitting, and homology modeling 1iga

Model of human IgA2 determined by solution scattering, curve fitting and homology modelling 1r70

• Fab and Fc Fragments

Refined crystal structure of the galactan-binding immunoglobulin fab j539 at 1.95-angstroms resolution 2fbj

Phosphocholine binding immunoglobulin fab mc/pc603. an x-ray diffraction study at 2.7 angstroms 1mcp

Phosphocholine binding immunoglobulin fab mc/pc603. an x-ray diffraction study at 3.1 angstroms 2mcp

Crystal structure of human FcaRI bound to IgA1-Fc 1ow0

Refined crystal structure of a recombinant immunoglobulin domain and a complementarity-determining region 1-grafted mutant 2imm and2imn

• Dimeric and Secretory

Solution structure of human dimeric immunoglobulin A 2qtj

Solution structure of human secretory IgA1 3chn

Solution Structure of Human SIgA2 3cm9

Solution structure of human secretory component 2ocw

ReceptorsReceptors

• Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR 1XED
• Crystal structure of human FcaRI 10vz
• Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human IgA1 2qej

Other Isotypes (for comparison)Other Isotypes (for comparison)

• IgM: Solution structure of human Immunoglobulin M 2rcj
• IgG:
• IgD:
• IgE: