Rebecca Martin/Sandbox1: Difference between revisions
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* Forms of IgA | * Forms of IgA | ||
Dimeric Structure | Dimeric Structure | ||
<applet load='2qtj' size='300' frame='true' align='right' caption=dimeric IgA1' /> | |||
<scene name='Rebecca_Martin/Sandbox1/Dimeric_iga_1/1'>dimeric iga</scene> | <scene name='Rebecca_Martin/Sandbox1/Dimeric_iga_1/1'>dimeric iga</scene> | ||
* Secretory Component | * Secretory Component | ||
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== IgA1 and IgA2 == | == IgA1 and IgA2 == | ||
<applet load='1r70' size='300' frame='true' align='right' caption='IgA2' /> <applet load='1iga' size='300' frame='true' align='right' caption='IgA1' /> | <applet load='1r70' size='300' frame='true' align='right' caption='monomeric IgA2' /> <applet load='1iga' size='300' frame='true' align='right' caption='monomeric IgA1' /> | ||
<applet load='3cm9' size='300' frame='true' align='right' caption=secretory IgA2' /> <applet load='3chn' size='300' frame='true' align='right' caption='secretory IgA1' /> | |||
<applet load='2ocw' size='300' frame='true' align='right' caption='secretory component' /> | |||
Revision as of 23:24, 22 April 2009
IgAIgA
IgA1
StructureStructure
- Immunoglobulin Structure
Antibodies are composed of a heavy chain and a light chain.
Fab fragment
- Forms of IgA
Dimeric Structure
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- Secretory Component
IgA1 and IgA2IgA1 and IgA2
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Secretory Component and Polyimmunoglobulin receptorSecretory Component and Polyimmunoglobulin receptor
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Insights into FunctionInsights into Function
EvolutionEvolution
Implications in Science and MedicineImplications in Science and Medicine
Limitations of the Current StudiesLimitations of the Current Studies
- Because of the nature of the IgA molecule, crystalizing this structure was not possible. Therefore, many of these structures are based on models and not actual crystal structures. Because ...., the models were depositable in the PDB. I tried to include other crystallographic data when available, supporting the proposed models- as the authors did in the original papers.
Questions for the FutureQuestions for the Future
- Because of the limitating resolution of these models, many details concerning the binding residues and residue interactions are left unknown. Crystallographic structure will yield further insights into the structure of IgA, the interactions between IgA and other molecules, and ....
LinksLinks
IgAIgA
- Monomeric
- Fab and Fc Fragments
- Refined crystal structure of the galactan-binding immunoglobulin fab j539 at 1.95-angstroms resolution 2fbj
- Phosphocholine binding immunoglobulin fab mc/pc603. an x-ray diffraction study at 2.7 angstroms 1mcp
- Phosphocholine binding immunoglobulin fab mc/pc603. an x-ray diffraction study at 3.1 angstroms 2mcp
- Crystal structure of human FcaRI bound to IgA1-Fc 1ow0
- Refined crystal structure of a recombinant immunoglobulin domain and a complementarity-determining region 1-grafted mutant 2imm and2imn
- Dimeric and Secretory
ReceptorsReceptors
- Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR 1XED
- Crystal structure of human FcaRI 10vz
- Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human IgA1 2qej
Other Isotypes (for comparison)Other Isotypes (for comparison)
- IgM: Solution structure of human Immunoglobulin M 2rcj
- IgG:
- IgD:
- IgE: