Rebecca Martin/Sandbox1: Difference between revisions

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== Limitations of the Current Studies ==
== Limitations of the Current Studies ==
    Because of the nature of the IgA molecule, crystalizing this structure was not possible. Therefore, many of these structures are based on models and not actual crystal structures. Because ...., the models were depositable in the PDB. I tried to include other crystallographic data when available, supporting the proposed models- as the authors did in the original papers.
Because of the nature of the IgA molecule, crystalizing this structure was not possible. Therefore, many of these structures are based on models and not actual crystal structures. Because ...., the models were depositable in the PDB. I tried to include other crystallographic data when available, supporting the proposed models- as the authors did in the original papers.


== Questions for the Future ==
== Questions for the Future ==

Revision as of 17:06, 22 April 2009

IntroductionIntroduction

IgA1

Template:STRUCTURE 3cm9































General StructureGeneral Structure

  • Antibody Structure
  • Dimeric Structure

  • Secretory Component


IgA1 and IgA2IgA1 and IgA2

IgA2

Drag the structure with the mouse to rotate

IgA1

Drag the structure with the mouse to rotate





























Secretory Component and Polyimmunoglobulin receptorSecretory Component and Polyimmunoglobulin receptor

This is the secretory component.

Drag the structure with the mouse to rotate




























Insights into FunctionInsights into Function

EvolutionEvolution

Implications in Science and MedicineImplications in Science and Medicine

Limitations of the Current StudiesLimitations of the Current Studies

Because of the nature of the IgA molecule, crystalizing this structure was not possible. Therefore, many of these structures are based on models and not actual crystal structures. Because ...., the models were depositable in the PDB. I tried to include other crystallographic data when available, supporting the proposed models- as the authors did in the original papers.

Questions for the FutureQuestions for the Future

Because of the limitating resolution of these models, many details concerning the binding residues and residue interactions are left unknown. Crystallographic structure will yield further insights into the structure of IgA, the interactions between IgA and other molecules, and ....











LinksLinks

IgAIgA

  • Model of human IgA1 determined by solution scattering, curve-fitting, and homology modeling 1iga
  • Model of human IgA2 determined by solution scattering, curve fitting and homology modelling 1r70
  • Crystal structure of human FcaRI bound to IgA1-Fc 1ow0
  • Solution structure of human dimeric immunoglobulin A 2qtj
  • Solution structure of human secretory IgA1 3chn
  • Solution Structure of Human SIgA2 3cm9
  • Solution structure of human secretory component 2ocw

ReceptorsReceptors

  • Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR 1XED
  • Crystal structure of human FcaRI 10vz
  • Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human IgA1 2qej

For ComparisonFor Comparison

  • IgM: Solution structure of human Immunoglobulin M 2rcj
  • IgG:
  • IgD:
  • IgE:


ReferencesReferences

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Rebecca Martin, Jaime Prilusky
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