2fvc: Difference between revisions

Revision as of 09:13, 15 April 2009

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File:2fvc.png

Template:STRUCTURE 2fvc

Crystal structure of NS5B BK strain (delta 24) in complex with a 3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinoneCrystal structure of NS5B BK strain (delta 24) in complex with a 3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinone

Template:ABSTRACT PUBMED 16451063

About this StructureAbout this Structure

2FVC is a 2 chains structure of sequences from Hepatitis c virus subtype 1b. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Tedesco R, Shaw AN, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Fitch DM, Gates A, Gerhardt WG, Halegoua DL, Han C, Hofmann GA, Johnston VK, Kaura AC, Liu N, Keenan RM, Lin-Goerke J, Sarisky RT, Wiggall KJ, Zimmerman MN, Duffy KJ. 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones , potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem. 2006 Feb 9;49(3):971-83. PMID:16451063 doi:10.1021/jm050855s

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OCA

[1] Tedesco R, Shaw AN, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Fitch DM, Gates A, Gerhardt WG, Halegoua DL, Han C, Hofmann GA, Johnston VK, Kaura AC, Liu N, Keenan RM, Lin-Goerke J, Sarisky RT, Wiggall KJ, Zimmerman MN, Duffy KJ. 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones , potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem. 2006 Feb 9;49(3):971-83. PMID:16451063 doi:10.1021/jm050855s

[xtra 1]

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 [[Category: Hcv polymerase]]
 [[Category: Thiadiazin inhibitor]]
+[[Category: Transferase]]
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