3f82: Difference between revisions
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{{STRUCTURE_3f82| PDB=3f82 | SCENE= }} | |||
===Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide=== | |||
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{{ABSTRACT_PUBMED_19260711}} | |||
==Disease== | |||
Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Renal cell carcinoma, papillary, familial and sporadic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Autism, suseptibility to, 9 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]] | |||
==About this Structure== | |||
3F82 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F82 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:19260711</ref><references group="xtra"/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Receptor protein-tyrosine kinase]] | |||
[[Category: Sack, J.]] | |||
[[Category: Alternative splicing]] | |||
[[Category: Atp-binding]] | |||
[[Category: Glycoprotein]] | |||
[[Category: Grb2]] | |||
[[Category: Membrane]] | |||
[[Category: Nucleotide-binding]] | |||
[[Category: Phosphoprotein]] | |||
[[Category: Proto-oncogene]] | |||
[[Category: Receptor tyrosine kinase]] | |||
[[Category: Shc]] | |||
[[Category: Signal transduction]] | |||
[[Category: Transferase]] | |||
[[Category: Transmembrane]] | |||
[[Category: Tyrosine-protein kinase]] | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 15:30:14 2009'' | |||
Revision as of 15:30, 2 April 2009
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamideCrystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Template:ABSTRACT PUBMED 19260711
DiseaseDisease
Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]
About this StructureAbout this Structure
3F82 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Schroeder GM, An Y, Cai ZW, Chen XT, Clark C, Cornelius LA, Dai J, Gullo-Brown J, Gupta A, Henley B, Hunt JT, Jeyaseelan R, Kamath A, Kim K, Lippy J, Lombardo LJ, Manne V, Oppenheimer S, Sack JS, Schmidt RJ, Shen G, Stefanski K, Tokarski JS, Trainor GL, Wautlet BS, Wei D, Williams DK, Zhang Y, Zhang Y, Fargnoli J, Borzilleri RM. Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluor ophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily. J Med Chem. 2009 Mar 12;52(5):1251-4. PMID:19260711 doi:http://dx.doi.org/10.1021/jm801586s
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