Triose Phosphate Isomerase: Difference between revisions
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=== Acid Base Catalysis === | === Acid Base Catalysis === | ||
Glutamate 165 plays the role of the general acid-base catalyst in a proton abstraction mechanism as it abstractluts a proton from carebon 1, which then donates it to carbon 2. Glutamate 165 requires Histidine 95, the general acid | |||
[[Image:TPI mechanism.jpg]] | [[Image:TPI mechanism.jpg]] | ||
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== Structure & Function == | == Structure & Function == | ||
<scene name='Triose_Phosphate_Isomerase/Helices/1'> | <scene name='Triose_Phosphate_Isomerase/Helices/1'>TextToBeDisplayed</scene> | ||
== Disease == | == Disease == | ||
=== Triose Phosphate Isomerase Deficiency === | === Triose Phosphate Isomerase Deficiency === | ||
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== References == | == References == | ||
Triose Phosphate Isomerase [[http://en.wikipedia.org/wiki/Triosephosphate_isomerase]] | |||
Triose Phosphate Isomerase Deficiency [[http://en.wikipedia.org/wiki/Triose_Phosphate_Isomerase_deficiency]] | Triose Phosphate Isomerase Deficiency [[http://en.wikipedia.org/wiki/Triose_Phosphate_Isomerase_deficiency]] | ||
Revision as of 03:51, 20 March 2009
'Triose Phosphate Isomerase
OverviewOverview
(TPI or TIM) which catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate, an essential process in the glycolytic pathway.
MechanismMechanism
TPI catalyzes the transfer of a hydrogen atom from carbon 1 to carbon 2, an intramolecular oxidation-reduction. This isomerization of a ketose to an aldose proceeds through an enediol intermediate.<Biochemistry 6th Edition>
Acid Base CatalysisAcid Base Catalysis
Glutamate 165 plays the role of the general acid-base catalyst in a proton abstraction mechanism as it abstractluts a proton from carebon 1, which then donates it to carbon 2. Glutamate 165 requires Histidine 95, the general acid
Diagram .<ref name= "web.virginia.edu" [1]
Structure & Function
<scene name='Triose_Phosphate_Isomerase/Helices/1'>TextToBeDisplayed</scene>
DiseaseDisease
Triose Phosphate Isomerase DeficiencyTriose Phosphate Isomerase Deficiency
See AlsoSee Also
ReferencesReferences
Triose Phosphate Isomerase [[2]] Triose Phosphate Isomerase Deficiency [[3]]